Injuries: Jedrick Wills (ankle), JC Tretter (knee), Jack Conklin (knee), Chris Hubbard (kneecap)
Backups: (T): Chris Hubbard, James Hudson (G): Michael Dunn Blake Hance, (C): Nick Harris
Fantasy Impact: The Browns are a stellar example of successfully going all-in on the O-line, and it comes as no surprise to see the team return all five starters after a stellar 2020 campaign. LG Joel Bitonio, C J.C. Tretter, RG Wyatt Teller and RT Jack Conklin are all among the league's best options at their positions, and if LT Jedrick Wills can improve upon an up and down rookie season, this unit could legitimately be without any real weakness among its starters. Add in a lethal RB duo of Nick Chubb and Kareem Hunt, and the Browns have a clear recipe for reliable offensive production.
Injuries: Quenton Nelson (ankle), Braden Smith (foot), Mark Glowinski (knee), Sam Tevi (ACL)
Backups: (T): Sam Tevi (G): Danny Pinter, Chris Reed (C): Joey Hunt
Fantasy Impact: The only reason for Indianapolis O-line trending 'down' is because this unit ranked No. 1 last season. The loss of longtime standout LT Anthony Castonzo signifies a seachange for the Colts, and though a healthy Eric Fisher should serve as a reliable replacement, the fact that the 30-year-old suffered a torn Achilles tendon during the AFC Championship Game leaves reason for concern. The presence of standouts Quenton Nelson and Branden Smith makes up for most of those worries, though, and should guarantee Carson Wentz solid protection (at the very least) in his inaugural year with the Colts.
Backups: (T): Brad Seaton, Josh Wells (G): Ryan Jensen, Robert Hainsey (C): Donnell Stanley
Fantasy Impact: Last year's Super Bowl champs made a predictable to return all five starters along the O-line, and also added depth rather than rest on their laurels. Tom Brady will once again enjoy outstanding pass protection in his age-44 season, while Leonard Fournette and Ronald Jones stand to benefit from more than solid run blocking. In the event that RT Tristan Wirfs manages to improve upon what was already a spectacular rookie season, this is a unit that could have even further upside.
Backups: (T): Ethan Greenidge (G): Derrick Kelly, Nick Easton, Will Clapp (C): Will Clapp
Fantasy Impact: Boasting what's arguably the best tackle duo in the league - Terron Armstead and Ryan Ramczyk - has been foundational for New Orleans' offense for years. Even with big changes potentially coming 2021, the luxury of a top-five O-line should provide the Saints with valuable stability for whomever of Jameis Winston and Tayson Hill is lining up under center. If 2020 first-round pick Cesar Ruiz can take a step forward in his development after a lackluster rookie year, it will provide further optimism for the future.