Injuries: Sadarius Hutcherson (knee, IR), Donell Stanley (undisclosed, IR), Ryan Jensen (knee)
Backups: (T): Brad Seaton, Josh Wells (G): Ryan Jensen, Robert Hainsey (C): Donnell Stanley
Fantasy Impact: Last year's Super Bowl champs made a predictable decision to return all five starters along the O-line, and also added depth rather than rest on their laurels. Tom Brad is once again enjoying outstanding pass protection in his age-44 season, while Leonard Fournette and Ronald Jones benefit from more than solid run blocking. Above all, this unit has avoided substantial injury attrition through the regular season, setting things up well for a potential postseason run.
Injuries: Josh Ball (ankle, IR), Mitch Hyatt (knee, IR)
Backups: (T): Terrence Steele, Ty Nsekhe (G): Connor Williams (C): Connor Williams
Fantasy Impact: Perennially one of the league's few elite O-line, the Cowboys had to endure a worst-case scenario up front in 2020. Season-ending injuries to both Pro Bowl tackles, Tyron Smith and La'el Collins, proved far too significant to overcome. Losing Dak Prescott and star guard Zack Martin for the year certainly didn't help matters. Now that the unit has returned to full health, as long as things break right, top-five upside could once again be in view.
Injuries: JC Tretter (knee), Jack Conklin (kneecap, IR), Chris Hubbard (triceps, IR)
Backups: (T): Chris Hubbard, James Hudson (G): Michael Dunn Blake Hance, (C): Nick Harris
Fantasy Impact: The Browns are a stellar example of successfully going all-in on the O-line, and it comes as no surprise to see the team return all five starters after a stellar 2020 campaign. LG Joel Bitonio, C J.C. Tretter, RG Wyatt Teller and RT Jack Conklin are all among the league's best options at their positions, and if LT Jedrick Wills can improve upon an up and down rookie season, this unit could legitimately be without any real weakness among its starters. That is, of course, dependent on health, and injuries haven't been kind to the Browns to begin the season. Conklin ultimately being forced to undergo season-ending surgery is a huge blow for Cleveland's offense.
Injuries: Mike Remmers (knee, IR), Lucas Niang (kneecap, IR)
Backups: (T): Wyatt Miller (G): Nick Allegritti, Yasir Durant (C): Creed Humphrey
Fantasy Impact: The memory Kansas City's loss to the Buccaneers in Super Bowl LV, in which the O-line was unable to give Patrick Mahomes any sort of consistent protection, led to a full overhaul of the unit. Gone are longtime tackles Eric Fisher and Mitchell Schwartz. New RT Lucas Niang's injury is a notable blow, but having traded for standout Orlando Brown from Baltimore solidifies the LT slot. Finishing the job by signing high-end LG Joe Thuney to an enormous contract in free agency, while also bringing in C Austin Blythe from the Rams, the Chiefs could potentially have a top-five unit if things mesh right. The starting RG is a bit more of a question.