Fantasy Baseball Scene in Knocked Up
For context, the Leslie Mann character thinks the Paul Rudd character is cheating on her. But it's worse, he's playing fantasy baseball and lying to his wife about it.
Beyond it's general awesomeness, there are two particular aspects of this scene that I love. First, I love the jerk sitting next to the Paul Rudd character. Every draft has this jerk and often I am that guy. Second, it's when Rudd says "I got Matsui".